Lipid Homeostasis

Common variants associated with plasma triglycerides and risk for coronary artery disease
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride …
Global Lipids Genetics Consortium
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Discovery and refinement of loci associated with lipid levels
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol …
Global Lipids Genetics Consortium
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Genetic determinants of lipid homeostasis
Circulating levels of blood lipids are heritable risk factors for atherosclerosis and heart disease, and are the target of therapeutic …
Elizabeth H. Young, Theodore Papamarkou, Nicholas W. J. Wainwright, Manjinder S. Sandhu
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A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol
Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of …
ENGAGE Consortium
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Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts
Background: Both genome-wide association studies and candidate gene studies have reported that the major determinant of plasma levels …
Delilah Zabaneh, Meena Kumari, Manj Sandhu, Nick Wareham, Nick Wainwright, Theodore Papamarkou, Jemma Hopewell, Robert Clarke, KaWah Li, Jutta Palmen, Philippa J. Talmud, Florian Kronenberg, Claudia Lamina, Monika Summerer, Bernhard Paulweber, Jackie Price, Gerry Fowkes, Marlene Stewart, Fotios Drenos, Sonia Shah, Tina Shah, Juan-Pablo Casas, Mika Kivimaki, John Whittaker, Aroon D. Hingorani, Steve E. Humphries
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